Publications
Book Chapters:
- Mittler, R. (1998) Cell death in plants. In: When Cells
Die, A Comprehensive Evaluation of Apoptosis and Programmed
Cell Death, Z.
Zakeri, J.Tilly, R.A.Lockshin (eds.), John Wiley & Sons, pp.
147-174.
- Cheung, A. and Mittler R. (2003) Programmed cell death in
plants. In: When Cells Die II, A Comprehensive Evaluation of Apoptosis
and Programmed
Cell Death, Z. Zakeri, J.Tilly, R.A. Lockshin (eds.), John
Wiley & Sons. pp. 99-122.
- Mittler, R. and Zilinskas, B. (2003) Active oxygen species
in multiple stress situations and protective systems. In:
Ecological Studies Vol. 170.
Springer, Berlin. pp 51-70.
- Mittler, R. and Shulaev, V. (2003) Programmed cell death in
plants: future perspectives, applications and
methods. In: Programmed Cell Death in
Plants, J. Gray (ed.) Blackwell Publishing. Oxford, UK pp.
251-264.
- Rizhsky, L. Shulaev, V. and Mittler, R. (2004) Measuring
apoptosis in plant cells. In: Apoptosis Methods and
Protocols, Methods in Molecular Biology. Humana Press. pp.
179-190.
- Shulaev, V. and Mittler, R. (2004) Programmed cell death in
plant yeast and bacteria. In: Essentials of
Apoptosis. Humana Press. pp. 125-134.
- Mittler R. (2004) The Hypersensitive Response. In:
Encyclopedia of Plant and Crop Science (online) Marcel
Dekker, Inc. New York. NY
- Mittler R. (2005) Ascorbate Peroxidase. In: Antioxidants
and reactive oxygen species in plants. Edited by N. Smirnoff.
Blackwell Publishing. Oxford, UK. 87-100.
- Miller G, Coutu, J. and Mittler, R. (2008) ROS signaling in
plants. In: Intracellular Signaling in Plants. Edited by
Z. Yang. Blackwell Publishing.
Oxford, UK. 189-201.
- Baxter A, Suzuki N and Mittler R (2012) Heat Tolerance in Plants. In Plant Abiotic Stress,
2nd Edition. Edited by Matthew A. Jenks and Paul M. Hasegawa. Wiley-Blackwell
Publishing. In press.
- Mittler, Ron. "Abiotic Stress." Plant Physiology and Development. By Lincoln Taiz, Eduardo Zeiger, Ian Max. Møller, and Angus Murphy. 6th ed. Sunderland: Sinauer Associates, 2015. 731-61. Print.
Research papers:
- Mittler, R. and Tel-Or, E. (1991) Oxidative stress response
and
shock proteins in the unicellular cyanobaterium Synechococcus
R2 (PCC 7942). Arch.
Microbiol. 155, 125-131.
- Mittler, R. and Tel-Or, E. (1991) Oxidative stress response
in the
unicellular cyanobacterium Synechococcus R2 (PCC 7942). Free Radical
Res. Comm. 12,
845-850.
- Mittler, R., Nir, M. and Tel-Or, E. (1991) Antiperoxidative
enzymes
in Retama and their seasonal variation. Free Radical Res. Comm. 14,
17-25.
- Rozen, A., Mittler, R. and Tel-Or, E. (1992) A unique
ascorbate
peroxidase activity in the cyanobacterium Synechococcus PCC 7942 (R2).
Free Radical Res. Comm. 17, 1-8.
- Mittler, R. and Zilinskas, B. (1991) Purification and
characterization of pea cytosolic ascorbate peroxidase. Plant Physiol.
97, 962-968.
- Mittler, R. and Zilinskas, B. (1991) Molecular cloning and
nucleotide sequence analysis of a cDNA encoding pea cytosolic ascorbate
peroxidase. FEBS
Lett. 289, 257-259.
- Mittler, R. and Zilinskas, B. (1992) Molecular cloning and
characterization of a gene encoding pea cytosolic ascorbate peroxidase.
J. Biol. Chem.
267, 21802-21807.
- Mittler, R. and Zilinskas, B. (1993) Detection of ascorbate
peroxidase activity in native gels by inhibition of
the ascorbate-dependent reduction of
nitroblue tetrazolium. Anal. Biochem. 212, 540-546.
- Mittler, R. and Zilinskas, B. (1994) Regulation of pea
cytosolic
ascorbate peroxidase and other antioxidant enzymes during the
progression of
drought stress and following recovery from drought. Plant J. 5,
397-406.
- Mittler, R., Shulaev, V. and Lam E. (1995) Coordinated
activation
of programmed cell death and defense mechanisms in transgenic tobacco
plants expressing a bacterial proton
pump. Plant Cell 7, 29-42.
- Mittler, R. and Lam, E. (1995) In situ detection of nDNA
fragmentation during the differentiation of trachear elements
in higher plants. Plant Physiol. 108, 489-493.
- Mittler, R. and Lam, E. (1995) Identification,
characterization,
and purification of a tobacco endonuclease activity induced upon
hypersensitive
response cell death. Plant Cell 7, 1951-1962.
- Mittler, R. and Lam, E. (1996) Sacrifice in the face of
foes: pathogen-induced programmed cell death in higher plants. Trends
Microbiol. 4, 10-15.
- Mittler, R., Shulaev, V., Seskar, M. and Lam, E. (1996)
Inhibition
of programmed cell death in tobacco plants during
pathogen-induced hypersensitive response at low oxygen pressure. Plant
Cell 8, 1991-2001.
- Mittler, R., Simon, L. and Lam, E. (1997) Pathogen-induced
programmed cell death in tobacco. J. Cell Science 110, 1333-1344.
- Mittler, R. and Lam, E. (1997) Characterization of nuclease
activities and DNA fragmentation induced upon hypersensitive response
cell death and mechanical stress. Plant Mol.
Biol. 34, 209-221.
- Mittler, R., Del Pozo, O., Meisel, L. and Lam, E. (1997)
Pathogen-induced programmed cell death in plants: a possible
defense mechanism. Developmental Genetics 21, 279-289.
- Mittler, R., Feng, X. and Cohen, M. (1998)
Post-transcriptional
suppression of cytosolic ascorbate eroxidase expression during
pathogen-induced
programmed cell death in tobacco. Plant Cell 10, 461-474.
- Mittler, R., Shulaev, V., Lam, E. and Cohen, M. (1999)
Signals
controlling the expression of cytosolic scorbate peroxidase during
pathogen-induced
programmed cell death in tobacco. Plant Mol. Biol. 39, 1025-1035.
- Mittler, R., Hallak-Herr, E., Orvar, B.L., Van Camp, W.,
Willekens,
H., Inze, D. and Ellis, B.E. (1999) Transgenic tobacco plants with
reduced capability
to detoxify reactive oxygen intermediates are hyper-responsive to
pathogen infection. Proc. Natl. Acad.
Sci. USA. 96, 14165-14170.
- Mittler, R. and Rizhsky, L. (2000) Transgene-induced lesion
mimics.
Plant Mol. Biol. 44, 335-344. (cover photo)
- Mittler, R., Merquiol, E., Hallak-Herr, E., Kaplan, A., and
Cohen,
M. (2001) Living under a "dormant" canopy: a molecular acclimation
mechanism of the
desert plant Retama raetam. Plant J. 25, 407-416. (cover photo)
- Rizhsky, L. and Mittler, R. (2001) Inducible expression of
bacterio-opsin in transgenic tobacco and tomato plants. Plant Mol.
Biol. 46, 313-323.
- Mittler, R. (2002) Oxidative stress, antioxidants, and
stress
tolerance. Ternds Plant Sci. 7, 405-410.
- Pekker, I., Tel-Or, E. and Mittler, R. (2002) Reactive
oxygen
intermediates and glutathione regulate the expression of cytosolic
ascorbate
peroxidase during iron-mediated oxidative stress in bean. Plant Mol.
Biol. 49, 429-438.
- Pontier D., Mittler R. and Lam E. (2002) Mechanism of cell
death
and disease resistance induction by transgenic expression of
bacterio-opsin Plant J. 30, 499-509.
- Pnueli, L., Hallak-Herr, E., Rozenberg, M., Cohen, M.,
Goloubinoff,
P., Kaplan, A. and Mittler, R. (2002) Molecular and biochemical
mechanisms associated
with dormancy and drought tolerance in the desert legume
Retama raetam.
Plant J. 31, 319-330.
- Rizhsky, L. Hallak-Herr, E., Van Breusegem, F.,
Rachmilevitch, S.,
Rodermel, S., Inzé, D. and Mittler, R. (2002) Double antisense plants
with suppressed
expression of ascorbate peroxidase and catalase are less sensitive to
oxidative stress than single
antisense plants with suppressed expression of ascorbate peroxidase or
catalase. Plant J. 32, 329-342.
- Merquiol, E., Hallak-Herr, E., Kaplan, A., Cohen, M. and
Mittler,
R. (2002) Seasonal and diurnal variations in gene
expression in the desert legume Retama raetam Plant Cell &
Environment. 25, 1627-1638.
- Rizhsky, L., Hongjian, L. and Mittler, R. (2002) The
combined
effect of drought stress and heat shock on gene expression in tobacco.
Plant Physiol.
130, 1143-1151.
- Lieman-Hurwitz, J., Rachmilevitch S., Mittler, R., Marcus,
Y. and
Kaplan, A., (2003) Enhanced photosynthesis and
growth of transgenic plants that express ictB, a gene involved in HCO3-
accumulation in cyanobacteria. Plant Biotech. J. 1, 43-50.
- Pnueli, L., Liang, H. and Mittler, R. (2003). Growth
suppression,
abnormal guard cell response, and augmented induction of heat shock
proteins in cytosolic ascorbate peroxidase (Apx1) - deficient
Arabidopsis plants. Plant J. 34, 187-203.
- Rizhsky L, Liang H, Mittler R. (2003) The water-water cycle
is
essential for chloroplast protection in the absence of stress. J. Biol.
Chem. 278, 38921-38925.
- Thornburg, R., Carter, C., Powell, A., Horner, H.H.,
Rizhsky, L.,
Mittler, R. (2003) A major function of the nectary gland is plant
defense against microbial attack. Plant Syst. Evol. 238, 211-218.
- Mittler. R., Vanderauwera, S., Gollery, M., Van Breusegem,
F.
(2004) The reactive oxygen gene network of plants. Trends
Plant Sci. 9, 490-498. (cover photo)
- Rizhsky L., Liang H., Shuman J., Shulaev V., Davletova S.
and
Mittler R. (2004) When defense pathways collide: The response of
Arabidopsis to a combination of drought and heat stress. Plant Physiol.
134, 1683-1696.
- Rizhsky L., Davletova S., Liang H. and Mittler R. (2004)
The
zinc-finger protein Zat12 is required for cytosoli ascorbate peroxidase
1 expression during
oxidative stress in Arabidopsis. J. Biol. Chem. 279, 11736-11743.
- Davletova S, Rizhsky L, Liang H, Shengqiang Z, Oliver DJ,
Coutu J,
Shulaev V, Schlauch K, Mittler R (2005) Cytosolic ascorbate peroxidase
1 is a central
component of the reactive oxygen gene network of Arabidopsis. Plant
Cell 17, 268-281.
- Davletova S, Schlauch K, Coutu J, Mittler R (2005) The
zinc-finger
protein Zat12 plays a central role in reactive oxygen and
abiotic stress signaling in Arabidopsis. Plant Physiol. 139,
847-856.
- Suzuki N, Rizhsky L, Liang H, Shuman J, Shulaev V, Mittler
R (2005)
Enhanced tolerance to environmental stresses in transgenic
plants expressing the
transcriptional co-activator MBF1. Plant Physiol. 139,
1313-1322.
- Suzuki N, Mittler R (2006) Reactive oxygen species and
temperature
stresses: A delicate balance between signaling and
destruction. Physiol. Plant. 126, 45-51.
- Mittler. R (2006) Abiotic Stress, the Field Environment and
Stress
Combination. Trends Plant Sci. 11, 15-19. (cover photo)
- Miller G, Mittler R (2006) Could plant HSFs function as
hydrogen
peroxide sensors? Ann. Bot. 98, 279-288.
- Bailey-Serres, J., Mittler, R. (2006) The Roles of Reactive
Oxygen
Species in Plant Cells. Plant Physiology Special Issue
on Reactive Oxygen Species. Plant Physiol. 141, 311. (cover photo)
- Gadjev, I., Vanderauwera, S., Gechev, T.S., Laloi, C.,
Minkov,
I.N., Shulaev, V., Apel, K., Inze, D., Mittler, R., Van Breusegem, F.
(2006) Transcriptomic footprints disclose specificity of reactive
oxygen species signaling in Arabidopsis. Plant
Physiol. 141, 436-445.
- Gollery M, Harper J, Cushman J, Mittler T, Girke T, Zhu
J-K,
Bailey-Serres J, Mittler R (2006) What Makes Species
Unique? The Contribution of Proteins with Obscure Features. Genome
Biol. 7(7):R57 [Epub ahead of print].
- Mittler R, Song L, Coutu J, Coutu A, Ciftci S, Kim YS, Lee
H,
Stevenson B, Zhu, J-K (2006) Gain- and loss-of-function mutations in
Zat10 enhance the
tolerance of plants to abiotic stress. FEBS Lett. 580, 6537-6542.
- Gollery M, Harper J, Cushman J, Mittler T, Mittler R (2007)
POFs:
what we don’t know can hurt us. Trends Plant Sci. 12, 492-496.
- Ciftci-Yilmaz S, Morsy MR, Song L, Coutu A, Krizek BA,
Lewis MW,
Warren D, Cushman J, Connolly EL, Mittler R
(2007) The ear-motif of the C2H2 zinc-finger protein
ZAT7 plays a key role in the defense response of Arabidopsis
to
salinity stress. J Biol Chem. 282, 9260-9268.
- Koussevitzky S, Nott A, Mockler T.C, Hong F,
Sachetto-Martins G,
Surpin M, Lim J, Mittler R, and Chory J (2007) Multiple signals from
damaged
chloroplasts converge on a common pathway to regulate nuclear gene
expression. Science 316, 715-719.
- Miller G, Suzuki N, Rizhsky L, Hegie A, Koussevitzky S,
Mittler R
(2007) Double mutants deficient in cytosolic and
thylakoid ascorbate peroxidase reveal a complex mode of interaction
between reactive
oxygen species, plant development and response to abiotic stresses.
Plant Physiol. 144,
1777-1785.
- Rivero RM, Kojima M, Gepstein A, Sakakibara H, Mittler R,
Gepstein
S, Blumwald E (2007) Delayed leaf senescence
induces extreme drought tolerance in a flowering plant. Proc Natl Acad
Sci U S A. 104, 19631-19636.
- Ciftci-Yilmaz S, Mittler R (2008) The zinc finger network
of
plants. Cell Mol Life Sci. 65, 1150-1160.
- Suzuki N, Bajad S, Shuman J, Shulaev V, Mittler R (2008)
The
transcriptional co-activator MBF1c is a key regulator of
thermotolerance in Arabidopsis thaliana. J
Biol Chem 283, 9269-9275.
- Shulaev V, Cortes D, Miller G, Mittler R (2008)
Metabolomics for
plant stress response. Physiol Plant. 132, 199-208.
- Morsy M, Gouthu S, Orchard S, Thorneycroft D, Harper JF,
Mittler R,
Cushman JC. (2008) Charting plant interactomes:
possibilities and challenges. Trends Plant Sci. 13, 183-191.
- Miller G, Shulaev V, Mittler R (2008) Reactive oxygen
signaling and
abiotic stress. Physiol Plant. 133, 481-489.
- Horan K, Jang C, Bailey-Serres J, Mittler R, Shelton C,
Harper JF,
Zhu JK, Cushman JC, Gollery M, Girke T (2008) Annotating genes of known
and unknown
function by large-scale coexpression analysis. Plant Physiol. 147,
41-57.
- Van Breusegem F, Bailey-Serres J, Mittler R (2008)
Unraveling the
tapestry of networks involving reactive oxygen
species in plants. Plant Physiol. 147, 978-984.
- Luhua S, Ciftci-Yilmaz S, Harper J, Cushman J, Mittler R
(2008)
Enhanced tolerance to oxidative stress in transgenic
Arabidopsis plants expressing proteins of unknown function. Plant
Physiol. 148, 280-292.
- Koussevitzky S, Suzuki N, Huntington S, Armijo L, Sha W,
Cortes D,
Shulaev V, Mittler R (2008) Ascorbate peroxidase 1 plays a key role in
the response of
Arabidopsis thaliana to stress combination. J Biol Chem. 283,
34197-34203.
- Chaudhary B, Hovav R, Flagel L, Mittler R, Wendel JF (2009)
Parallel expression evolution of oxidative stress-related
genes in fiber from wild and domesticated diploid
and polyploid cotton (Gossypium). BMC
Evolutionary Biology, 10:378.
- Tunc-Ozdemir M, Miller G, Kim J, Sodek A, Koussevitzky S,
Misra AM,
Luhua S, Mittler R, Shintani D (2009) Thiamin confers enhanced
tolerance to oxidative stress in Arabidopsis. Plant Physiol. 151,
421-32.
- Chang F-I, Curran A, Woolsey R, Quilici D, Cushman J,
Mittler R,
Harmon A, Harper J, (2009) Proteomic profiling of tandem affinity
purified 14-3-3 protein
complexes in Arabidopsis thaliana. Proteomics 9, 2967-85
- Miller G, Schlauch K, Tam R, Cortes D, Torres MA, Shulaev
V, Dangl
JL, Mittler R (2009) The plant NADPH oxidase RbohD mediates rapid,
systemic signaling in response to diverse stimuli. Science Signaling.
18;2(84):ra45. (cover photo)
- Miller G, Honig A, Stein H, Suzuki N, Mittler R,
Zilberstein A
(2009) Unraveling delta1-pyrroline-5-carboxylate (P5C)/proline cycle in
plants by uncoupled expression of proline oxidation enzymes. J Biol
Chem. 284, 26482-92.
- Mittler R, Blumwald E (2010) Genetic engineering for modern
agriculture: Challenges and perspectives. Ann. Rev. Plant
Biol. 61:443-62.
- Miller G, Suzuki N, Ciftci-Yilmaz S, Mittler R. (2010)
Reactive
oxygen species homeostasis and signalling during drought and salinity
stresses. Plant Cell Environ. 33(4):453-67.
- Vanderauwera S, Suzuki N, Miller G, van de Cotte B, Morsa
S,
Ravanat JL, Hegie A, Triantaphylidès C, Shulaev V, Van Montagu MC, Van
Breusegem F, Mittler R. (2011) Extranuclear protection of chromosomal
DNA from oxidative stress. Proc Natl Acad Sci U S
A. 108(4):1711-6.
- Shulaev V, Sargent DJ, Crowhurst RN, Mockler TC, Folkerts
O,
Delcher AL, Jaiswal P, Mockaitis K, Liston A, Mane SP, Burns P, Davis
TM, Slovin JP, Bassil N, Hellens RP, Evans C, Harkins T, Kodira C,
Desany B, Crasta OR, Jensen RV, Allan AC, Michael TP, Setubal JC,
Celton JM, Rees DJ, Williams KP, Holt SH, Rojas JJ, Chatterjee M, Liu
B, Silva H, Meisel L, Adato A, Filichkin SA, Troggio M, Viola R, Ashman
TL, Wang H, Dharmawardhana P, Elser J, Raja R, Priest HD, Bryant DW Jr,
Fox SE, Givan SA, Wilhelm LJ, Naithani S, Christoffels A, Salama DY,
Carter J, Girona EL, Zdepski A, Wang W, Kerstetter RA, Schwab W, Korban
SS, Davik J, Monfort A, Denoyes-Rothan B, Arus P, Mittler R, Flinn B,
Aharoni A, Bennetzen JL, Salzberg SL, Dickerman AW, Velasco R,
Borodovsky M, Veilleux RE, Folta KM. (2011) The genome of woodland
strawberry (Fragaria vesca). Nat Genet. 43(2):109-16. (cover photo)
- Mittler R, Vanderauwera S, Suzuki N, Miller G, Tognetti VB,
Vandepoele K, Gollery G, Shulaev V, Van Breusegem F (2011) ROS
signaling: The new wave? Trends in Plant Sciences. 16(6):300-9. (cover photo)
- Suzuki N, Sejima H, Tam R, Schlauch K, Mittler R (2011)
Identification of the MBF1 heat-response regulon of Arabidopsis
thaliana. Plant J. (2011) 66, 844–851.
- Zuris J.A, Harir Y., Conlan A.R., Shvartsman M., Tamir S., Paddock M.L., Mittler R., Cabantchik Z.I., Jennings P.A., Nechushtai R. (2011) Facile transfer of [2Fe-2S] cluster from a diabetes target to an acceptor protein. Proc. Natl. Acad. Sci. USA, 108(32):13047-52
- Nechushta R, Conlan A, Song L, Harir Y, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Shulaev V, Paddock ML, Cabantchik I, Jennings PA, Mittler R (2012) Arabidopsis thaliana ChloroNEET, a Member of the New NEET Family of Human Proteins, is Involved in Development, Senescence and Iron Metabolism. Plant Cell. 24:2139-2154
- Suzuki N, Miller G, Morales J, Shulaev V, Torres MA, Mittler R (2011) Respiratory burst oxidases: The engines of ROS signaling. Curr. Opin. Plant Biol. 14(6):691-9
- Suzuki N, Koussevitzky S, Mittler R, Miller G (2012) ROS and redox signaling in the response of plants to abiotic stress. Plant Cell Environ. 35(2):259-70.
- Mittler R, Finka A, Cuendet FA, Goloubinoff P (2012) How do plants feel the heat? Trends Biochem Sci. 37(3):118-25.
- Nechushtai R, Conlan AR, Harir Y, Song L, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Paddock ML, Cabantchik ZI, Jennings PA, Mittler R. (2012) Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism. Plant Cell. 2012 May;24(5):2139-54. doi: 10.1105/tpc.112.097634.
- Suzuki N, Mittler R. (2012) Reactive oxygen species-dependent wound responses in animals and plants. Free Radic Biol Med. 53(12):2269-2276.
- Lunua S, Hegie A, Suzuki N, Shulaev E, Luo X, Harper J, Cushman J, Gollery M, Girke T, Bailey-Serres J, Stevenson RA, Zhu J-K, Mittler R. (2012) Annotating plant genes of unknown function: A large-scale screen for altered tolerance to abiotic stress. Physiol Plant. 148(3):322-33.
- Suzuki N, Miller G, Sejima H, Harper J, Mittler R. (2013) Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2. J Exp Bot. 64(1):253-63.
- Tunc-Ozdemir M, Tang C, Ishka MR, Brown E, Groves NR, Myers CT, Rato C, Poulsen LR, McDowell S, Miller G, Mittler R, Harper JF (2013) A cyclic nucleotide-gated channel (CNGC16) in pollen is critical for stress tolerance in pollen reproductive development. Plant Physiol. 161(2):1010-20.
- Suzuki N, Miller G, Salazar C, Mondal HA, Shulaev E, Cortes DF, Shuman JL, Luo X, Shah J, Schlauch K, Shulaev V, Mittler R. (2013). Temporal-spatial interaction between ROS and ABA controls rapid systemic acclimation in plants. Plant Cell. 25(9):3553-69.
- Mittler R, Shulaev V. (2013) Functional genomics, challenges and perspectives for the future. Physiol Plant. 148(3):317-21. (cover photo)
- McDowell SC, Akmakjian G, Sladek C, Mendoza-Cozatl D, Morrissey JB, Saini N, Mittler R, Baxter I, Salt DE, Ward JM, Schroeder JI, Guerinot ML, Harper JF. (2013) Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions. PLoS One. 8(5):e63014.
- Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R. (2013) Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs. PLoS One. 8(5):e61202.
- Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V,
Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R. (2013) NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A. 110(36):14676-81.
- Rivero RM, Mestre TC, Mittler R, Rubio F, Garcia-Sanchez F, Martinez V. (2014) The combined effect of salinity and heat reveals a specific physiological, biochemical and molecular response in tomato plants. Plant Cell Environ. 37(5):1059-73.
- Baxter A, Mittler R, Suzuki N. (2014) ROS as key players in plant stress signalling. J Exp Bot. 65(5):1229-40.
- Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. (2014) Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proc Natl Acad Sci U S A. 111(14):5177-82.
- Suzuki N, Rivero RM, Shulaev V, Blumwald E, Mittler R. (2014) Abiotic and biotic stress
combinations. New Phytol. Apr 11. doi: 10.1111/nph.12797. Invited Tansley Review.
- Gilroy S, Suzuki N, Miller G, Choi1 WG, Toyota M, Reddy A, Mittler R. (2014) A tidal wave of signals: Calcium and ROS at the forefront of rapid systemic signaling. Trends in Plant Sci. Invited review (cover photo)
- Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler
R, Jennings PC, Livnaha O, Nechushtai R (2014) A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Cryst D.
- Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings PA, Mittler R, Nechushtai R. (2015) Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim Biophys Acta. Invited review.
- Mittler R and Blumwald E. (2015) The roles of ROS and ABA in systemic acquired accumulation. Plant Cell.
- Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings PA, Onuchic JN, Mittler R, Nechushtai R. (2015) The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3698-703. doi: 10.1073/pnas.1502960112.
Commentary:
- Mittler, R. and Berkowitz, G. (2001) Hydrogen peroxide, a
messenger
with too many roles? Pei Z.M., Murata Y., Benning G. et al,
Nature 2000; 406: 731-734. Redox Report 6, 69-72.
Patents:
- U.S. Patent No. 5,629,470 entitled "Transgenic Plants and
Plant
Cells with Enhanced Pathogen Resistance and
Related Methods"; International Application Number PCT/US96/00741 (Jan.
1996);
Inventors: Lam, E. and Mittler, R.
- U.S. Patent No. 20,020,042,931 entitled "Enhancing Inorganic Carbon
Fixation by
Photosynthetic Organisms" (June 1999); Inventors: Kaplan,
A., Lieman-Hurwitz, J., Mittler, R., Ronen-Tarazi, M., Bonfil, D. and
Schatz, D